International Journal of Pharmaceutical Science and Research


International Journal of Pharmaceutical Science and Research


International Journal of Pharmaceutical Science and Research
International Journal of Pharmaceutical Science and Research
Vol. 1, Issue 5 (2016)

Synthesis and biological evaluation of some new pyrazole derivatives


Mohamed A. Hamed, Ahmed A El Gokha, Ramzy Essam R Abdelwahed, Asem A Mohamed, Abdel Moneim EL-Torgoman, Ibrahim El-Tantawy El Sayed

The synthesis of a novel of pyrazole derivatives was achieved by condensation of acetyl furan with phenyl hydrazine to give hydrazone (1) On the other hand, cyclization of α, β-unsaturated ketone. Using Vilsmeier reagent by DMF (dimethylformamid) and POCl3 Phosphorus oxychloride) to give compound (2). The chemical structures of all new compounds were established by IR, ¹HNMR, and mass spectra data. All the synthesized compounds were screened for in vitro antibacterial activity and most of them showed potency against both gram positive and gram negative bacteria. Compounds 4-(α-benzoyl aminoacrylic acid)-3-Furayl-1-phenylpyrazol, 4-(α- benzoylamino methyl acrylate)-3-Furayl-1-phenylpyrazol,4-(2-4-dinitrophen ylhydrazone)-3-Furayl-1-phenylpyrazole showed the highest antibacterial activity against Bacillus subtilis strain with minium inhibition zone 19 mm.
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