According to the international association for the study of pain, pain is “an unpleasant sensory and emotional experience associated with actual and potential tissue damage, or described in terms of such damage, or both. Thus pain has objective, physiologic sensory aspects as well as subjective emotional and psychological components. The term “Nociception” is used only to describe the neural response to traumatic or noxious stimuli. Pain is often mistreated or undertreated and can lead to depression, insomnia, lethargy and reduced physical and mental functioning. The successful drug management of pain relies on selecting the appropriate drug at the correct dosage and balancing efficacy against adverse effects.