International Journal of Pharmaceutical Science and Research

Authors
B Srujan Reddy, Ananda Kumar Chettupalli

Abstract
The current research was carried out with the intention of developing a topical gel formulation of itraconazole, which is the study's stated objective. Itraconazole is a kind of imidazole derivative that is used in the treatment of both systemic and local forms of fungal infection. Itraconazole shouldn't be taken by mouth too often since it might cause a lot of unpleasant side effects. This formulation was created for better patient compliance, to reduce the dose of the drug, and to avoid side effects such as liver damage and kidney damage, which are not available in commercially available itraconazole topical gel preparations on the market. Commercially available itraconazole topical gel preparations do not exist. Changing the polymer ratio was one step in the process of formulating the gel. By making use of an appropriate polymer, a number of formulations (F1, F2, F3, F4, and F5) were produced (carbopol 934p and HPMC). The formulation was analysed for its percentage yield, spread ability, extrudability, wash ability, and viscosity. Additionally, it underwent stability testing, a skin irritation research, and drug release testing. One of the steps in the process of creating the gel was changing the proportion of the polymer. The use of an appropriate polymer allowed for the production of a number of formulations, which were denoted by the letters F1, F2, F3, F4, and F5 (carbopol 934p and HPMC). The formulation was evaluated in a number of different ways, including its % yield, spread ability, extrudability, wash ability, and viscosity. In addition to that, it was examined for its stability, its potential to irritate the skin, and its potential to release drugs.