International Journal of Pharmaceutical Science and Research

Authors
Girgis Samuel, Uddin Nazim, Ankur Sharma, Veena Manuel

Abstract
Nano carriers (NCs) have been established as drug carriers to be a gifted targeted drug delivery systems for cancer therapy. The physicochemical properties of NCs can be modified for improvements in the pharmacokinetic and pharma co-dynamic profiles for practical uses.CK-10 is a novel synthetic peptide that can significantly inhibit the RAN overexpression in malignant tissue and therefore it can successfully prevents the metastatic growth. However, CK10 still suffers from the traditional practical hurdles of the other peptides like poor stability, short half-life, and liability to digestion by proteases. Loading the CK-10 within various PLGA nanoparticles has the potential to solve such problems for treating cancer. Design of a novel PLGA nanoparticle by a novel microfluidics techniques is sufficient to optimize physicochemical properties. The novel microfluidic technique has succeeded to improve the physicochemical properties all the PLGA nanoparticles by enhancement of the peptide loading, decreasing the size and narrowing the polydispersity index compared to the double emulsion/solvent evaporation technique. PLGA/Poloxomer and PLGA/B cyclo dextrin formed by the novel microfluidic technique have higher CK-10 loading efficiencices (56.13 & 52.92) with suitable size range (200 to 260) for targeting the cancer tissues. PLGA/Poloxomer blend has the smallest size which is a vital parameter for targeting the cancer/tumor tissue. The successful development of better physicochemical properties for the CK-10 loaded PLGA nanoparticles can improve the RAN blocking by CK-10.