Many neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington’s disease, amyotrophic lateral sclerosis, multiple sclerosis and psychiatric disorders, occur as a result of progressive degeneration or death of neuron cells. There are many herbal drugs having efficacy in neurodegenerative diseases. Modern phytopharmaceutical research can facilitate brain targeting of herbal medicines in the form of Novel Drug delivery System (NDDS) like nanoparticles, microemulsions, matrix systems, solid dispersions, liposomes, phytosomes, transdermal drug delivery systems, and ethosomes. NDDS may play a vital role to cross the blood-brain barrier in neurodegenerative disorders. Nowadays the number of NDDS has been developed to achieve controlled and targeted drug delivery in the bloodstream. NDDS also opens a new door for delivery of herbal drugs at accurate concentration, a study of the mechanism of action and provide a scientific way for standardization of herbal drugs. The present review highlights the existing status of the development of novel herbal drug delivery systems for the neuroprotective effect.