International Journal of Pharmaceutical Science and Research


International Journal of Pharmaceutical Science and Research


International Journal of Pharmaceutical Science and Research
International Journal of Pharmaceutical Science and Research
Vol. 4, Issue 2 (2019)

Antioxidant and antimicrobial activities of ethanolic extracts of onions (Allium cepa) and shallots (Allium ascalonicum) cultivated in Vietnam


Pham Van Hung, Nguyen Quynh Hai Yen

The objective of this study was to evaluate the antimicrobial and antioxidant capacities of four Allium species grown in Vietnam including purple onion, white onion, purple shallot and white shallot. Under ethanolic extraction, the highest total phenolic and total flavonoid content was detected in purple onion (22.66 ± 1.35 mg FAE/g dried sample and 11.00 ± 3.74 mg RE/g dried sample, respectively), which correlated to the strong antioxidant activity (84.70% for 50 mg/ml extract concentration) measured by DPPH-radical scavenging assay; white onion ranked second, neutralized 67.82% DPPH-radical; while purple shallot and white shallot ranked third for three mentioned criteria. The antimicrobial activities were tested against two gram-positive pathogenic bacteria: S. aureus and B. cereus (VTCCB-1005); and two gram-negative pathogenic bacteria: P. aeruginosa (ATCC-9027) and S. typhi - by agar well diffusion method and the dilution method for minimum inhibitory concentration (MIC). Although not being a prominent antioxidant in four test subjects, white shallot was appreciated for expressing the best antimicrobial activity, followed by purple onion and white onion. S. typhi resisted against all extracts while purple shallot showed no antimicrobial activity against reference strains. The distinction in growth suppression between gram negative and gram positive bacteria were not significant.
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