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VOL. 4, ISSUE 2 (2019)
Comparative In-vitro pharmaceutical evaluation of some selected brands of metronidazole tablets marketed in Iraq
Authors
Asmaa Abdelaziz Bayoumi, Hawraa Fattah, Shams Abd-al Rasoul, Mohammed Abd-Al Rasoul, Estabraq Jawad
Abstract
Objective: The aim of this study was to assess the quality of some selected metronidazole products in community pharmacies in Iraq Methods: Different parameters of quality control of pharmaceutical products can guarantee the quality and bioavailability and optimal therapeutic activity. Used quality control parameters, i.e., the variation of weight, friability, content uniformity, disintegration time and dissolution profiles were tested in vitro. Results: The weight range was 0.79-0.82 g, 0.74-0.78g, 0.82-0.86g, 0.95-0.97g, 0.63-0.72 g 0.62-0.65 g for Neogyl, Anaerobex, Metrobac, Negazole, Flazi-MD and Metrosule, respectively. Disintegration time was 11 min,5 min, 43 min, 7 min, 30 min, 12 min for Neogyl, Anaerobex, Metrobac, Negazole, Flazi-MD and Metrosule, consequently. Content uniformity was satisfactory and dissolution rate of all brands was more than 85% after 60 min except Anaerobex and neogyl whose dissolution rate was 83.06% and 80.22%. Conclusion: The results showed that all products fulfill the given specification of Pharmacopeia (USP-NF) which its dissolution rate was less than % in USP (85% after 60 min) except Anaerobex and neogyl. Disintegration of Anaerobex showed the quickest disintegration while Metrobac represented the slowest.
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Pages:13-15
How to cite this article:
Asmaa Abdelaziz Bayoumi, Hawraa Fattah, Shams Abd-al Rasoul, Mohammed Abd-Al Rasoul, Estabraq Jawad "Comparative <em>In-vitro</em> pharmaceutical evaluation of some selected brands of metronidazole tablets marketed in Iraq". International Journal of Pharmaceutical Science and Research, Vol 4, Issue 2, 2019, Pages 13-15
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