International Journal of Pharmaceutical Science and Research

International Journal of Pharmaceutical Science and Research


International Journal of Pharmaceutical Science and Research
International Journal of Pharmaceutical Science and Research
Vol. 3, Issue 4 (2018)

Development and evaluation of Rosuvastatin loaded bio-flexy film using a novel flexy film former from Cleome viscosa


Kirti Singh, NV Satheesh Madhav

The main objective of the study was the formulation and evaluation of bio-adhesive flexy films to deliver nanosized rosuvastatin. The bio-flexy films were aimed to deliver through the nabhi. A novel bio-film former was isolated from the seeds of a natural edible source, Cleome viscosa. The isolated biopolymer was screened for its film forming ability by preparing bi-flexy films of the isolated biopolymer by solvent casting method. Five formulations (RC1-RC5) were prepared by varying the polymer: drug ratios (1:1, 1:2, 1:3, 1:4, 1:5) by solvent casting method. Rosuvastatin was nanosized, and used as the model drug. The formulated bio-flexy films were tested for surface pH, thickness, weight variation, content uniformity, folding endurance. In-vitro study showed that formulation RC2 (1:2) was the best formulation having R2 value 0.9286, and Higuchi-Matrix as best fit model. The conclusion was drawn that the isolated biopolymer has good film forming capacity, and can be utilised for designing various pharmaceutical formulations.
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How to cite this article:
Kirti Singh, NV Satheesh Madhav. Development and evaluation of Rosuvastatin loaded bio-flexy film using a novel flexy film former from Cleome viscosa. International Journal of Pharmaceutical Science and Research, Volume 3, Issue 4, 2018, Pages 35-38
International Journal of Pharmaceutical Science and Research