International Journal of Pharmaceutical Science and Research

International Journal of Pharmaceutical Science and Research


International Journal of Pharmaceutical Science and Research
International Journal of Pharmaceutical Science and Research
Vol. 1, Issue 7 (2016)

Microwave assisted extraction of bioactive compound phyllanthin from Phyllanthus amarus and optimization using central composite design


Chanchal Garg, Sonia Verma, Saurabh Satija, Meenu Mehta, Harish Dureja, Munish Garg

Phyllanthus amarus has a long history of use in traditional medicine and phyllanthin is one of its potent compounds. Although various extraction methods are available but newer methods with increased efficiency are needed in the modern era. The objective of this study was to predict the optimum conditions for microwave-assisted extraction (MAE) of phyllanthin from Phyllanthus amarus using response surface methodology (RSM). A central composite design was applied to determine the effect of extraction time, irradiation power and methanol concentration on yield of phyllanthin. Optimum extraction conditions were predicted as 65% methanol concentration, 60% irradiation power and 3 minute extraction time. The phyllanthin content of 0.063% w/w was obtained which was higher than that of soxhlet and maceration extraction. The results were analysed statistically using one way analysis of variance (ANOVA).
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How to cite this article:
Chanchal Garg, Sonia Verma, Saurabh Satija, Meenu Mehta, Harish Dureja, Munish Garg. Microwave assisted extraction of bioactive compound phyllanthin from Phyllanthus amarus and optimization using central composite design. International Journal of Pharmaceutical Science and Research, Volume 1, Issue 7, 2016, Pages 30-35
International Journal of Pharmaceutical Science and Research International Journal of Pharmaceutical Science and Research