International Journal of Pharmaceutical Science and Research


International Journal of Pharmaceutical Science and Research


International Journal of Pharmaceutical Science and Research
International Journal of Pharmaceutical Science and Research
Vol. 1, Issue 5 (2016)

A screening study of rifampicin oral suspension formulation using plackett-burman design of experiment model


Kale SA, Bajaj VH

In the present study a screening design of experiments was applied in preliminary evaluation of oral suspension formulation of Rifampicin. Rifampicin is a widely used antibiotic to treat a several types of bacterial infections like tuberculosis, leprosy, and Legionnaire's disease. A Plackett-Burman screening design was used to identify significant variables affecting critical quality attributes (CQAs). Impact of formulation and manufacturing process variables like surfactant (%), hydrocolloid (%), homogenization speed (rpm) and homogenization time (min) was studied on critical quality attributes (CQAs) of Rifampicin oral suspension. Viscosity (cps) and content uniformity (% C.V.) were identified as CQAs of Rifampicin oral suspension.
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