International Journal of Pharmaceutical Science and Research

Authors
Zavalska TV, Lizogub VG, Bogdan VV, Sharayeva ML, Zhornіchenko DM

Abstract
We analyzed the effect of non-ischemic therapy based on variety of basic drugs for the treatment of unstable angina pectoris. The study involved 94 patients - men and women aged 59 to 74 years (mean age of patients were 67, 2 ± 5, 2 years). All patients diagnosed with unstable angina (UA). We compared the efficacy of antianginal therapy, which includes Aspirin, Beta-blockers (Bisoprolol), Statins (Atorvastatin), Nitrates (Cardiket), ACE inhibitors (Enalapril) (I group of patients) with antianginal therapy including Aspirin, Clopidogrel, Beta-blockers (Nebivolol), Statins (Rosuvastatin), Nitrates (Cardiket), ACE inhibitors (Enalapril), and L-arginine (II group of patients). All patients were assessed for dynamic clinical condition, ectopic activity and myocardial ischemia, Holter ECG monitoring were used. The treatment results were evaluated after 20-21 days at the end of treatment.rnThe criteria for assessing the effectiveness was the reduction of the number of angina attacks at the end of the treatment, reducing the number of nitrates tablets cupping, reducing episodes of silent myocardial ischemia (SMI), the pain of myocardial ischemia (PMI), the number of supraventricular complex (PVC) and ventricular premature beats (VC) were monitored on a daily basis by the use of Holter ECG (electrocardiogram HM).rnDuring treatment of the 1st group of patients, the number of angina attacks that needed nitrates, decreased by 56% from the third week of treatment: in 28 patients (61%) the number of angina attacks decreased by more than 50%, in 18 pts decreased by less than 50%. At the end of the treatment in patients of the main comparative group the number of angina attacks that needed taking nitroglycerin, decreased by 67%:in 36 patients (75%) the number of angina attacks decreased by more than 50%, in 12 pts decreased by less than 50%.rnThe treatment of patients showed pronounced antianginal and anti-ischemic effects: daily amount of pain episodes of myocardial ischemia (PMI), and silent myocardial ischemia (SMI) and the total duration of the data of ECG HM significantly reduced in both groups of patients. The total daily duration of SMI in the main second group patients with unstable angina after treatment became 2.3 times less compared with first group of patients. The total daily duration of BIM in patients with II group became 1.3 times less appeared than in compared patients after treatment.rnIn the comparative group of patients at the end of treatment the daily amount of supraventricular episodes reduced at least in 2 times, while in patients of main group - 3.2 times. The daily number of VCs in patients with the complex treatment became 1.7 times less compared with usually treated patients of the first group. rnThus, more intensive complex treatment of unstable angina with L-arginine leads to beneficial optimization of myocardial ischemia parameters