Assessment of microbiological quality and anti-bacterial traits of oral liquid drugs used in Bangladesh
Md Aminul Islam Apu, Shamsun Nahar Jolly, Mohammad Minnatul Karim
Microbial contamination into the pharmaceutical products is not unlikely due to a number of parameters including the imperfect good manufacturing practice as well as the imperfect total quality management. This study aimed to assess the microbiological quality and anti-bacterial traits of oral liquid drug used in Bangladesh. Nine (9) different types of liquid oral drugs were selected to determine the microbial load, presence of common pathogenic bacteria and antibacterial trait. Microbiological analysis was carried out using spread plate technique on different culture media including nutrient agar, Potato dextrose agar, MacConkey agar, EMB agar, Pseudomonas agar, SS agar and Mannitol salt agar for the determination of total viable bacteria, total fungi, total coliform, fecal coliform, Pseudomonas spp., Salmonella spp., Shigella spp., and Staphylococcus aureus respectively. Anti-bacterial traits were tested against Escherichia coli, Pseudomonas aeruginosa and Salmonella spp. using well diffusion method. The results revealed that all of the tested samples showed compliance with the official requirement of microbial quality as they did not show any common pathogenic organisms or did not show any growth or their count is within the USP permissible limit (<102 CFU/ml). Five (5) samples are exhibited the anti-bacterial activity as they showed zone of inhibition againstalmost all pathogens tested.