International Journal of Pharmaceutical Science and Research


International Journal of Pharmaceutical Science and Research


International Journal of Pharmaceutical Science and Research
International Journal of Pharmaceutical Science and Research
Vol. 4, Issue 4 (2019)

Formulation development and evaluation of Lornoxicam gel


Manish Mukati, Raju Choukse, Sourabh Jain, Dr. Karunakar Shukla

The transdermal anti-inflammatory gels containing Lornoxicam & different polymers, were prepared and evaluated for different parameters like pH, drug content & rheological properties like viscosity & spredability and results found were all satisfactory. The Results indicates that PLO gel shows better results than Carbopol Gel. All eleven formulations were also evaluated for In-vitro drug release study. Study was carried for 8 hrs for all formulation and results reported in table 9.3 shows that, the Formulation F-2 and F-4 showed good cumulative % Drug Release profile of Lornoxicam in 8 hr. But the linear curve shown in fig. 9.1 was obtained from F-2 formulation. The cumulative amount permeated from Carbopol gel through membrane was found to be 67% which was less than PLO Gel formulations. This indicates that PLO Gel has more drug permeation across the membrane than carbopol gel.
Pages : 27-37