Skin injury and wound healing are complex biological and compatible processes that involved in the activation of inter-cellular pathways, co-ordination of tissue integrity and homeostasis. The wound can be categorized into acute and chronic depending upon the nature and depth of injury. The important part of the wound healing is wound care dressing. Wide varieties of dressing materials are available to intensify the activity of wound healing. Numerous plants are reported to posses wound healing property. The consummate wound dressing biomaterial act as a three-dimensional template which can mimic extracellular matrix, be biologically stable, flexible and can remove the wound exudate by providing the moist environment to the wound site. It protects the wound from the external hazards and act as a bed. Now-a-days polymer-based biomaterial attracts the researcher for biomedical applications. This article presents a review of variety of polymer-based biomaterials, characteristic features, history, divisions, chemical structures and its formulations used in pharmaceuticals.