Vol. 3, Issue 3 (2018)
Antipyretic activity of methanolic fruit extract of Xylopia aethiopica in yeast-induced pyrexia
Author(s): Angela N Ukwuani Kwaja Yazeed U Jekada
Abstract: Xylopia aethiopica fruit singly or in combination with other medicinal herbs have been used in traditional medicine for the treatment of pain, inflammation and fever for many years among the Hausa communities of northern Nigeria. The aim of this study is to investigate the antipyretic effects of the methanolic fruit extract of Xylopia aethiopica in Brewer’s yeast-induced pyretic rats. Phytochemicals were qualitatively determined using standard procedures while the acute oral toxicity was determined using limit dose test and the invivo antipyretic activity was determined by brewer’s yeast induced pyrexia method. The results showed that the LD50 of methanol fruit extract of X. aethiopica was greater than 5000mg/kg and possessed significant (p<0.05) antipyretic effect by causing a decrease in rectal temperature. Treated animals (100 and 400mg/kg) exhibited fever reduction from the 3rd to the 6th hour which was not significantly different (p>0.05) from animal treated with the standard drug paracetamol. Phytochemicals present includes tannins, alkaloids, saponins, phenols, flavonoids, steroids and terpenoids. In conclusion, this study provides evidences for the antipyretic effect of fruit extract of Xylopia aethiopica which supports its ethno medical use.