International Journal of Pharmaceutical Science and Research


International Journal of Pharmaceutical Science and Research


International Journal of Pharmaceutical Science and Research
International Journal of Pharmaceutical Science and Research
Vol. 3, Issue 2 (2018)

Evaluation of the analgesic activity of Capsicum chinense in experimental animals


Dr. Diptimoyee Devi, Dr. Mandeep Sarma Basistha, Dr. Karishma Adhikari, Dr. Lakhimi Borah

Aims and Objectives: This study was undertaken with the objective of evaluating the analgesic activity of Capsicum chinense in experimental animals. Material and Methods: Ethical review: The present study was performed on mice (20-30 gm body weight) of both sexes. Plant material: Whole plant of Capsicum chinense will be collected and authenticated. Extraction of plant material: The shade dried and finely powdered fruits were extracted with 99.9% ethanol using Soxhlet apparatus. Acute toxicity study: Acute toxicity study was carried out according to the OECD 425 Guidelines. Experimental design: Group 1- Normal Control- Received Normal Saline at a dose of 10ml/kg per orally, Group 2- Disease Control- Acetic Acid 1% (1ml/100gm) i.p., Group 3- Standard- Diclofenac at a dose of 10 mg/kg i.p. + Acetic Acid 1% (1ml/100gm) i.p., Group 4- EECC 200 mg/kg per orally + Acetic Acid 1% (1ml/100gm) i.p., Group 5- EECC 400 mg/kg per orally + Acetic Acid 1% (1ml/100gm) i.p. Test for peripherally acting analgesic: Acetic acid induced writhing. Diclofenac was used as standard in this test.
Pages : 41-43