Formulation and evaluation of mucoadhesive buccal tablets of metoprolol succinate
Anka Rao A, Babu Rao CH, Devanna N
Buccaladhesive tablets that are prepared in the present investigation consist of usage of natural polymers which can prolong the drug release period of time. The drugs that are selected are of beta blockers which have short bioavailability and have greater need at the particular hour. The selection of buccaladhesive form to bypass first pass metabolism and degradation that occurs due to liver. These are adhesive forms which stay at the particular location and releases the drug due to swell in the polymer. Therefore all these advantages made the buccaladhesive system better when compared to other forms.
In this particular investigation the polymers that are selected are studied for viscosity at different concentrations, at different temperature conditions, different climatic conditions and also for stability. Different tests were performed which gives information regarding the nature of polymer. The formulations are planned by taking different concentrations of drug and polymers in varying concentrations from high to low. Based on this drug release is calculated and compared with that of the synthetic polymers. Natural polymers are named as NBA01, NBA02, NBA03 and NBA04.
The drug release is based upon swelling index and quantity of polymer. High viscosity is imparted with high concentration of polymer and vice versa. The optimized formulation is selected basing upon the maximum duration of drug release; this is further studied for stability followed by in vivo studies.