Vol. 3, Issue 1 (2018)
Synthesis and Antiproliferative activity of novel Acridine-biotin conjugates
Author(s): Shaban El Khabery, Mohamed A El-Bahnsawye, Ahmed Abdel Aleem El-Gokha, Amira A Salama, Ibrahim El-Tantawy El Sayed
Abstract: Acridine-biotin conjugates 7 were synthesized in good yields by coupling aminoalkylaminoa acridines 5 with biotin 6. The key starting diamines 4 were synthesized by reaction of 9-chloroacridine 3 with diamines 4. The structure of the synthesized compounds were elucidated by the spectroscopic tools and showed results consistence with the proposed structures. Furthermore, the antiproliferative activity for the synthesized compounds were evaluated against hepatocellular (HepG2), colon (HCT-116) and breast (MCF-7) carcinoma cell lines using colorimetric MTT assay. The screening results showed that compound 7l exhibits the best activity with IC50: 5.99, 8.84 and 7.80 µM against HepG2, HCT-116 and MCF-7 cancer cell lines respectively.