Vol. 2, Issue 3 (2017)
Development and standardization of Polyherbal formulation for the management of breast cancer
Author(s): Dhara Bhatt, Khushboo Jethva, Sonal Patel, Maitreyi Zaveri
Abstract: The incidence of breast cancer and related mortality is increasing annually. It is the leading cause of cancer death amongst women worldwide. The current chemotherapeutic agents render toxic effects to the body. Hence, there is a need to find the alternative cure for the management of breast cancer with minimal side effects. The popularity of herbal medicine is rapidly increasing in today’s time. The present study deals with development of the polyherbal formulation comprising of the hydro-alcoholic (30:70) extracts of Curculigo orchioides, Curcuma longa, Emblica officinalis, Teriminalia bellerica, Teriminalia chebula and Withania somnifera. For the standardization of the raw materials physicochemical studies like ash values, extractive values, phytochemical studies were performed. The Preformulation parameters and parameters for finished product (hard gelatin capsule) include uniformity of weight, disintegration time, moisture content, pH, phytochemical estimation were performed. The cytotoxic activity of the finished product was performed using MTT assay on MCF7 breast carcinoma cell line. The prepared finished product showed significant cytotoxic activity against MCF7 breast carcinoma cell line.