International Journal of Pharmaceutical Science and Research

International Journal of Pharmaceutical Science and Research

ISSN: 2455-4685

Vol. 2, Issue 2 (2017)

Anti-Pyretic potential of Artocarpus Heterophyllus Lam leaves on tab vaccine-induced pyrexia

Author(s): Battu Ganga Rao, Rayana Vijaya Poojitha, Devarakonda Ramadevi
Abstract: Ethanopharmacological relevances: Artocarpus heterophyllus leaves has been traditionally used in Ayurveda system of medicine to treat fever.
Aim of the study: The study investigates on methanolic extract of Artocarpus heterophyllus leaves for antipyretic potential in wistar rats.
Materials and methods: Fever was induced by administration of Typhoid, Para-typhoid A and B vaccine, diluted in 1/15 th part of saline, intra peritonially. The hyperexia in rats was measured using thermometer. Methanolic extract of Artocarpus heterophyllus leaves of dose 100, 200 and 400 mg per kg-1 body weight was administered to animals.
Results and Discussion: Methanolic extract of Artocarpus heterophyllus leaves of dose 400mg per kg-1 body weight produced significant reduction in elevated body temperature compared to that of standard Paracetamol 150 mg per kg-1 body weight. The obtained values are expressed as meanĀ±SEM values. Conclusion: Our results provides information regarding safety and effectiveness of Artocarpus heterophyllus leaves extract in treatment of fever.
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International Journal of Pharmaceutical Science and Research
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