International Journal of Pharmaceutical Science and Research


International Journal of Pharmaceutical Science and Research


International Journal of Pharmaceutical Science and Research
International Journal of Pharmaceutical Science and Research
Vol. 2, Issue 2 (2017)

Anti-Pyretic potential of Artocarpus Heterophyllus Lam leaves on tab vaccine-induced pyrexia


Battu Ganga Rao, Rayana Vijaya Poojitha, Devarakonda Ramadevi

Ethanopharmacological relevances: Artocarpus heterophyllus leaves has been traditionally used in Ayurveda system of medicine to treat fever.
Aim of the study: The study investigates on methanolic extract of Artocarpus heterophyllus leaves for antipyretic potential in wistar rats.
Materials and methods: Fever was induced by administration of Typhoid, Para-typhoid A and B vaccine, diluted in 1/15 th part of saline, intra peritonially. The hyperexia in rats was measured using thermometer. Methanolic extract of Artocarpus heterophyllus leaves of dose 100, 200 and 400 mg per kg-1 body weight was administered to animals.
Results and Discussion: Methanolic extract of Artocarpus heterophyllus leaves of dose 400mg per kg-1 body weight produced significant reduction in elevated body temperature compared to that of standard Paracetamol 150 mg per kg-1 body weight. The obtained values are expressed as meanĀ±SEM values. Conclusion: Our results provides information regarding safety and effectiveness of Artocarpus heterophyllus leaves extract in treatment of fever.
Pages : 47-49