Vol. 2, Issue 1 (2017)
LiClO4 catalysed one-pot synthesis of Novel α-aminophosphonates and study of their effects on (MCF7) breast cancer cell line and (HCT) colon carcinoma cell line
Author(s): Mohamed A Hamed, Ahmed A El Gokha, Eslam M. EL-Deab, Abdel Aleem El Gokha, Ibrahim El-Tantawy El Sayed
Abstract: The syntheses of a novel of N-protected α-aminophosphonates were achieved with high yields through lithium per chlorate catalyzed one-pot three component reaction process. It involves the reaction of benzyl carbamate, aldhydes and triphenyl phosphite using lithium perchlorate as Lewis acid catalyst in aceto nitrile at room temperature. The structures of all new compounds were established by IR, ¹HNMR and mass spectral data. On the other hand, Cleavage of the resulted α-aminophosphonates lead to the formation of a mine. Condensation reaction of the resulted amine with mono and disaccharides in presence of ethanol and gacial acetic acid. All the synthesized compounds were screened for in vitro antibacterial activity and most of them showed potency against both gram positive and gram negative bacteria. The chemical structures of all new compounds were established by IR, ¹HNMR, and mass spectra data.