International Journal of Pharmaceutical Science and Research

International Journal of Pharmaceutical Science and Research

ISSN: 2455-4685

Vol. 1, Issue 5 (2016)

Colon targeted drug delivery systems: A review on primary and novel approaches

Author(s): Dhyani Archana, Juyal Divya
Abstract: The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. This review, mainly compares the primary approaches for CDDS (Colon Specific Drug Delivery) namely prodrugs, pH and time dependent systems, and microbially triggered systems, which achieved limited success and had limitations as compared with newer CDDS namely pressure controlled colonic delivery capsules, CODESTM, and osmotic controlled drug delivery which are unique in terms of achieving in vivo site specificity, and feasibility of manufacturing process.
Pages: 40-47  |  1826 Views  1303 Downloads
International Journal of Pharmaceutical Science and Research
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