Vol. 1, Issue 5 (2016)
Synthesis and biological evaluation of some new pyrazole derivatives
Author(s): Mohamed A. Hamed, Ahmed A El Gokha, Ramzy Essam R Abdelwahed, Asem A Mohamed, Abdel Moneim EL-Torgoman, Ibrahim El-Tantawy El Sayed
Abstract: The synthesis of a novel of pyrazole derivatives was achieved by condensation of acetyl furan with phenyl hydrazine to give hydrazone (1) On the other hand, cyclization of α, β-unsaturated ketone. Using Vilsmeier reagent by DMF (dimethylformamid) and POCl3 Phosphorus oxychloride) to give compound (2). The chemical structures of all new compounds were established by IR, ¹HNMR, and mass spectra data. All the synthesized compounds were screened for in vitro antibacterial activity and most of them showed potency against both gram positive and gram negative bacteria. Compounds 4-(α-benzoyl aminoacrylic acid)-3-Furayl-1-phenylpyrazol, 4-(α- benzoylamino methyl acrylate)-3-Furayl-1-phenylpyrazol,4-(2-4-dinitrophen ylhydrazone)-3-Furayl-1-phenylpyrazole showed the highest antibacterial activity against Bacillus subtilis strain with minium inhibition zone 19 mm.