International Journal of Pharmaceutical Science and Research

International Journal of Pharmaceutical Science and Research

ISSN: 2455-4685

Vol. 1, Issue 3 (2016)

Investigation of Ximenia Americana leaf extract for anti-ulcer effects using ethanol-induced gastric ulcer model in rats

Author(s): P Vasanth Kumar, K vijaya, M Siddaiah
Abstract: The antiulcer effects of the aqueous extract of ximenia americana leaves were investigated using ethanol-induced gastric ulcer model in rats. The extract was prepared by refluxed successively with ethanol in soxhlet extractor for 72 hrs. A yield of 15.30% w/w dry extract was obtained. ximenia americana extract (AEXA) exhibited a more gastro-protective effect against ethanol-induced stomach ulcers at 150,300 and 600 mg/kg than Ranitidine (50mg) and solvent treated (control) rats. AEXA had 66.73%, 47.22% while Ranitidine produced 79.71%. lesions were observed to deviate from massive severe lesions with marked disorientation of the gastric epithelium in the control to fairly protected mucosa with Ranitidine and a better protected mucosa with intact epithelium in AEXA (150,300 mg/kg) treated rats. AEXA extract was found to be significantly protective against ethanol-induced gastric ulcers in the experimental rats.
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